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Sikiric P, Drmic D, Sever M, et al

In breast cancer cells, a high level of miR-378* induces the metabolic shift from an oxidative to a glycolytic bioenergetics pathway by inhibiting the expression of two PGC-1 partners, ERR (estrogen-related receptor gamma) and GABPA (GA binding protein transcription factor, alpha subunit)

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These doses are typically lower than traditional treatment regimens, potentially ranging from 0.25mg to 0.5mg weekly, aiming for sustained benefits with minimal side effects

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Efficacy and safety of glucagon-like peptide-1 receptor agonists on body weight and cardiometabolic parameters in individuals with obesity and without diabetes: a systematic review and meta-analysis