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disease-associated neural network behavior (expressed in vitro) Key limits of this approach the brain is dynamically changing

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Post-mortem examinations of MS patients brains showed typical inflammatory T cells, and macrophages perivascular infiltrates, along with myelin degradation and axons degeneration, but demyelinated lesions can occur anywhere within the brain and spinal cord, giving to the disease complexity, and heterogeneity of clinical signs, and symptoms (Kuhlmann et al., 2008)

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