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Results Combination treatment with metformin and liraglutide is more effective than single treatment to protect against palmitic acid (PA)-induced endothelial dysfunction In cultured human umbilical vein endothelial cells (HUVECs), PA induced endothelial dysfunction, characterized by increased reactive oxygen species (ROS) production, decreased NO level and reduced intracellular phosphorylated endothelial NO synthase (p-eNOS) protein level, in a concentration-dependent manner (Fig

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In addition to this, it also reduces the build up of lactic acid in the muscles to prevent muscle fatigue

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Call a provider if leg spots spread, look purple, do not fade with pressure, or come with fever, swelling, bruising, or pain

The answer depends on the study, dose, population, treatment length, and whether the medication is approved or investigational