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Virus-specific T cells are important to control HSV, and proliferation of activated T cells requires increased metabolism of glutamine

Deficit of this nutrient in the human diet leads to impaired glucose metabolism, disruption of bioenergetic processes, mitochondrial dysfunction, lactic acidosis (the result of mitochondrial dysfunction of pyruvate dehydrogenase), suppressed DNA synthesis due to low transketolase activity and ribose-5-phosphate synthesis in the pentose phosphate pathway, and disrupted neurotransmitter synthesis

Consistent weekly dosing is essential

Each study participant was also taking stable oral medication

Front Aging Neurosci 9 Cohen J, D'Agostino L, Tuzer F, Torres C (2018) HIV antiretroviral therapy drugs induce premature senescence and altered physiology in HUVECs

Jaisinghani explains