Furthermore, when we performed GSEA for each of the chondrocyte differentiation stages separately, we observed that among the three upregulated pathways, protein processing in ER was ranked highest in resting chondrocytes, but proteasome was top-ranked in columnar and ferroptosis in hypertrophic chondrocytes, suggesting that the phenotype progressively evolves during chondrocyte differentiation from a homeostatic adaptive response to cell death (Extended Data Fig
190,191 SIRT1-3 maintain the chromatin structure via deacetylation of a crucial histone residue, H4K16
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Curcumin-based fluorescent and colorimetric probe for detecting cysteine in living cells and zebrafish
PMCID: PMC8275860
