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Resveratrol supplementation in obese patients mimicked the effects of caloric restrictionactivation of AMPK, increase in SIRT1 and PGC-1 protein levels, increase in citrate synthase activity without change in mitochondrial content, and improved muscle mitochondrial respiration were found [135]

Lautenbach A, Wernecke M, Huber TB, Stoll F, Wagner J, Meyhfer SM, et al

The study was approved by the Committee on Human Subjects, Joslin Diabetes Center (Boston, Massachusetts, USA)

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Mammucari, Regulation of skeletal muscle growth by the IGF1-Akt/PKB pathway: insights from genetic models