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Furthermore, when using cholesterol hydroperoxide (ChOOH, a specific GPX4 substrate) as a stressor, compound 102 could activate GPX4 in intact cells and protect them from ChOOH toxic effects ( Supplementary Figure S12B )

The research further examines the structural dimension, indicative of a crucial asparagine residue in the NOX1-p22phox complex, vital for the electron transfer process in human NADPH oxidases (108)

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Fortunately, when we are young, our bodies produce enough glutathione