The Leyden 2002 clinical evaluation in the Journal of Cosmetic Dermatology compared a copper tripeptide cream and serum against placebo in 67 women with photodamaged skin and found significant improvements in wrinkle depth, skin laxity, clarity, and density at 12 weeks [30]
A second tissue slide was stained using a mouse monoclonal anti-Ki67 antibody (Menarini Diagnostics, Firenze, Italy
Gastrointestinal issues Nausea, stomach discomfort, and diarrhea may occur temporarily after taking a high dose of vitamins and minerals
Infect Drug Resist 13:40474060
Treatment focuses on relieving symptoms with antihistamines or corticosteroids
Combining microneedling with topical GHK-Cu is a logical protocol you're getting the mechanical stimulation benefit and improving delivery simultaneously