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reported that although 74% of patients engaged in some form of exercise and 64% received educational support, only 19% adhered to all first-line guideline-consistent treatments, highlighting implementation gaps in clinical settings (Mazzei et al., 2022)

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Moreover, fat mass in rats on the fcHFHS diet was significantly higher compared to rats on the fcHS and fcHF diets [ F (3,20) = 13,65

The psychosocial impact is further compounded by the frequent misdiagnosis or underdiagnosis of the condition, which can delay appropriate care.27 Several studies have demonstrated that the quality of life in patients with lipedema is markedly reduced compared to age-matched controls.15,17,28 Some of the tools used included assessments of symptom severity, quality of life, satisfaction with life, psychological flexibility, and social connectedness

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