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Inclusion and exclusion criteria The following criteria were used to determine which studies were eligible based on the PICOS principles 32 : 1) participants were aged 18 years with a diagnosis of AD or with cognitive impairment without a diagnosis of AD

Brightening Effect: L-Ascorbic Acid has a brightening effect on the skin, helping to fade dark spots and even out skin tone

doi:10.1371/journal.pone.0162590 24

Decades of published research document how it works: it supports blood flow through smooth muscle relaxation

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