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At treatment initiation, the median BMI was 34.9 kg/m 2 (IQR: 32.038.6) and the median %EWL was 40.6% (IQR: 27.952.7)

In the LEAN trial, Liraglutide was shown to have a higher rates of NASH resolution and lower rates of fibrosis progression compared to placebo

This tripartite interaction plays a central role in the pathogenesis of various diseases, particularly metabolic disorders such as type 2 diabetes and obesity (Figure 2)

Oral semaglutide (Rybelsus) is available for type 2 diabetes treatment

Adults 65 and older have the highest diabetes rate of any age group, about 29%, yet their GLP-1 use drops to 9%, below the middle-aged group and below the national average

Detailed TRIUMPH-1 data is expected to be presented at the 86th American Diabetes Association Scientific Sessions later in 2026