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Additional study is required to clarify the molecular pathways that drive ferroptosis-related chondrocyte death and cartilage deterioration

The study suggested that bariatric surgery promotes significant weight loss, which is associated with improvement in IR, hyperandrogenism, menstrual irregularity, and ovulatory dysfunction [63]

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Rotate sites systematically (abdomen, thighs, upper arms) to avoid lipohypertrophy [10]

Therefore, the androgen/estrogen ratio is modified in germ cells, and if testosterone is involved in the regulation of testicular functions, estrogens are also necessary not only in the control of gonadotropins secretion but also in the modulation of the Leydig cells development and steroidogenesis, as well as in the development and/or maintenance of spermatogenesis and spermiogenesis in some mammalian species (15)

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