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103 Interestingly, sleep deprivation has been shown to reduce synthesis of serotonin and melatonin from tryptophan, instead favoring tryptophan breakdown into compounds that may have toxic effects in the brain

Supports Healthy Neurological Function : The brain's high oxygen consumption makes it particularly vulnerable to oxidative stress

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Several hypotheses have been postulated to explain how these amylin aggregates can cause -cell loss due to their toxic effects [27]

Furthermore, p62 is also an autophagy substrate, and it is used as an autophagy marker [280]