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Major fluid retention, very if accompanied by shortness of breath, rapid weight gain, or other concerning symptoms, needs medical evaluation to rule out more serious conditions

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The studies are consistent with the hypothesis that SAMe administered orally is bioavailable in an active form or as an active metabolite in the brain

Johanson 2007)

These symptoms could signal complications like erosive esophagitis (inflammation of the esophageal lining) or, in rare cases, Barrett's esophagusa condition requiring specialist evaluation

Yu et al., 2013)