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Besides, toxicity screening performed on several types of metal oxide NPs observed that CuO and ZnO NPs induced the highest toxicity in acute models both in vitro and in vivo , mainly due to significant promotion of pro-inflammatory cytokines release and inhibition of macrophage viability (Areecheewakul et al., 2020)

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MI complements this redox balance by enhancing IRS-PI3K/Akt signaling, which reduces ROS generation secondary to hyperinsulinemia and excessive lipid oxidation