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Interferon-gamma (IFN-) is released from both activated T-cells and natural killer cells and attenuates gut barrier integrity by promoting the endocytic uptake of TJ components such as claudin (Prasad et al

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In a mouse model of allergic rhinitis, it exerts anti-allergic effects by suppressing the Th2 response, thereby reducing IgE and histamine levels, inhibiting the TLR4/MyD88/NF-B pathway to attenuate inflammation, and promoting Th1 activation while restoring the Th1/Th2 immune balance (Li et al., 2023a