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Because weak carbonic-anhydrase inhibition can precipitate non-anion-gap metabolic acidosis, caution or avoidance is warranted in patients with chronic metabolic acidosis, severe pulmonary disease with chronic hypercapnia, or conditions pre-disposing to osteoporosis, nephrolithiasis, or nephrocalcinosis

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[5] Pramlintide has been approved on 3/16/2005 by the FDA, for use by type 1 and type 2 diabetic patients who use insulin

Improving hydration often provides noticeable improvement in both symptoms

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