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doi: 10.1016/j.bcp.2017.09.003 33 RasheedARaynerKJ

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Cell 145 , 607621 (2011)

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Eligibility and dosing The tablet is licensed for adults with obesity, with a body mass index (BMI) of 30 or above, or those who are overweight with a BMI between 27 and 30 with at least one weight-related comorbidity, alongside a reduced-calorie diet and increased physical activity

Another line of evidence comes from studies on NAD+ and insulin resistance