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Abstract Background In children, recombinant human growth hormone (rhGH) therapy for treatment of short stature has raised concerns of the early onset of puberty

However, considering the mechanism of this drug class, questions remain regarding the carcinogenic potential

Because of this activity, L-carnitine is concentrated in tissues that preferably use fatty acids as a fuel, namely the heart and skeletal muscle, where about 95% of total body L-carnitine is stored

Simpson and Oliver, 2020

The need for diagnosis, treatment and prevention of AITD is also due to the need to prevent concomitant diseases, including disorders of the cardiovascular system, hypercholesterolemia, atrial fibrillation, encephalopathy, others autoimmune diseases ( Cellular and humoral immunity in the pathogenesis of AITD In addition to genetic, cellular and humoral immune mechanisms, loss of immune tolerance to thyroid autoantigens is the basis for the development of AITD