Constipation, obstipation, and megacolon
Obesity Management: The STEP UP trial demonstrated significant weight loss with semaglutide 7.2mg, with participants losing 20.7% of their body weight after 72 weeks, compared to 17.5% with the 2.4mg dose and only 2.4% with placebo
Appearance : Sunken or hollow under-eyes with dark shadows
Sparkling water, either plain or with a squeeze of fresh lemon or lime, offers a fizzy alternative to diet soda without artificial sweeteners
Standard protocols range from 0.25mg to 0.5mg daily via subcutaneous injection for 4 to 8 weeks
Women should contact their GP or specialist if they develop severe or persistent symptoms potentially related to oestrogen changes, including: Significant worsening of menopausal symptoms (hot flushes, night sweats, mood changes) Vaginal dryness or discomfort affecting quality of life Unexplained changes in libido or sexual function Symptoms suggestive of bone health concerns (unexplained fractures, significant height loss) Mood disturbances or depressive symptoms Seek urgent medical attention if you experience: Severe, persistent abdominal pain (especially radiating to the back) with or without vomiting, which could indicate pancreatitis Upper right abdominal pain, fever, or yellowing of the skin/eyes, which might suggest gallbladder disease Signs of dehydration (extreme thirst, dry mouth, reduced urination, dizziness) Suspected pregnancy while taking semaglutide Routine monitoring during semaglutide treatment should follow NICE guidance for diabetes management or weight management programmes
