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The elevation of inflammatory mediators such as JNK and IB kinase (IKK) in hypothalamic inflammation may also explain the obesity induced by HFD

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It plays an important role in the body's metabolism, as it helps to transport fatty acids into the mitochondria, the energy-producing units of cells, where they can be burned for fuel

Patients beginning GLP-1 receptor agonist therapy sometimes report changes in skin texture, redness, or heightened sensitivity to environmental triggers

Immunologic effects Smoking profoundly impacts both innate and adaptive immunity, often aggravating pathological immune responses while suppressing defensive mechanisms [19]

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