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Furthermore, existing studies have shown that opioid dependence can influence the epigenetic landscape, morphological structure, and neurotransmitter secretion in brain regions such as the prefrontal cortex (PFC), Nucleus Accumbens (NAc), and amygdala [8,13,14]

Loss of growth hormonemediated signal transducer and activator of transcription 5 (STAT5) signaling in mice results in insulin sensitivity with obesity