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Search strategy The following databases were searched for studies in humans published in the English language: PubMed (MEDLINE), EMBASE, SPORTDiscus, Cochrane Library, Web of Science and ClinicalTrials.gov, with no restriction placed on the date of publication (from inception to March 2022), including published abstracts

Whilst gastrointestinal side effects are well documented, some patients report sleep disturbances, including insomnia, during treatment

This method may also reduce the risk of some side effects that occur when a drug interacts with stomach acids or digestive enzymes

doi:10.3390/ph18020185 Gwyer D, Wragg NM, Wilson SL

Science 292 , 104106 (2001)

Clinical Evidence for GLP-1 and DPP-4 Combination Use Medical literature on simultaneous GLP-1 agonist and DPP-4 inhibitor use remains limited, and combination therapy is not routinely recommended by major diabetes guidelines