Despite the limited expression of GLP-1 receptors in the cardiac tissue, they tend to enhance the myocardial function through multiple mechanisms, including optimizing the coronary vascular smooth muscle cells, and endothelial function of the coronary microvasculature and the peripheral vessels as well, in addition to improving blood glucose control and providing alternative energy substrates like ketones and lactate
By contrast, none of the mainstream guidelines, including those from the International Association for the Study of Pain (IASP
The short answer is noand attempting this combination carries documented cardiovascular risks
Duan H, Cai X, Luan Y, et al
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