The Role of the Kidneys and Natriuresis Beyond the brain, GLP-1 medications have a direct effect on your kidneys
You can skip any "loading phase." For anyone on a GLP-1 who is also doing resistance training, creatine is the clearest evidence-backed value on this list
Parkinsons Disease Applications Just as in Alzheimers disease, GLP-1RAs are being looked at for treatment of Parkinsons disease
3ac), but with further improved glucose tolerance and insulin sensitivity and further decreased blood glucose and insulin (Fig
On one hand, a large 2024 cohort study (over 160,000 patients with obesity) reported a significantly higher incidence of new psychiatric diagnoses among GLP-1 RA users: an ~98% increase in risk of any psychiatric disorder compared to matched non-users, including a 195% higher risk of major depression and ~106% higher risk of suicidal behavior (Scientific Reports 2024)
Retatrutide and tirzepatide are often compared because they represent the next wave of metabolic medications, but theyre not equally accessible
