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That said, the compound has not been through full Phase III trials or FDA drug approval
Both approaches have merit
These conditions involve impaired copper handling that could make even topical copper application problematic
In a 26-week rat oral toxicity study, AOD-9604 produced dose-dependent changes in serum osteocalcin (a bone-turnover marker) at week 13, with the direction reversing by week 26
The rabbits were euthanized via carbon monoxide inhalation nine weeks after the first collagenase injection for subsequent examination [1]
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