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Comparative trials show that long-acting medications (exenatide once weekly, liraglutide, dulaglutide, and semaglutide) provide better glycemic control than short-acting medications (exenatide twice daily and lixisenatide) [90]

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However, formal contraindications will be more clearly defined as phase 3 trial data mature

Ray EC, Boyd-Shiwarski CR, Liu P, Novacic D, Cassiman D

Endocrinology, 158 ,

The Shanghai Osteoarthritis Cohort study found lower rates of knee surgery among GLP-1 users 39