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Because oral glutathione is poorly absorbed and rapidly degraded in the gut, it is not often used in clinical trials

JAMA, 291 (24), 29782984

Cross-trial comparisons suggest survodutide may achieve greater absolute weight loss, but differences in trial design, patient populations, and endpoints make direct comparison unreliable

The augmentation of enzalutamides effects with semaglutide treatment could be clinically meaningful for improving the efficacy of enzalutamide in CRPC patients or used as a singular therapeutic approach for NEPC patients

Within the SGLT2i cohort, 47% received empagliflozin, 27% received dapagliflozin and 25% received canagliflozin

This relatively short plasma half-life initially suggests the need for frequent dosing to maintain therapeutic concentrations