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Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans

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The TT-OAD2 (brown stick and transparent van der Waals surface) binding triggers the reorganization of the interaction network at the top of TM1 and leads the Y1481.43 and Y1521.47 to make contact and form hydrogen bond interactions with the R1902.60

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