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STEP-1 Wilding 2021 NEJM: -14.9% at 2.4mg/68w for semaglutide vs -24.2% at 12mg/48w for retatrutide
Tang, H., Zhang, B., Lu, Y., Donahoo, W
Reporting them early guides care plans, like adjusting the dose or incorporating supportive care to ease the treatment burden
If your appetite suppression is weakening, your side effects are worsening, or you are not losing weight at the expected rate, message your provider
That also means side effects at higher doses are real, and earning your dose over time is not optional it's the strategy
This pattern mirrors what we see with other weight loss medications and may relate to differences in baseline body composition
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