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The honest position is therefore that orforglipron appears to bring peptide-class- range efficacy in an oral small molecule a genuinely notable result without having demonstrated superiority to the best injectables, and while sitting below the top of the injectable efficacy distribution

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"From a consumer-buyer-beware standpoint, anytime you consume or inject something where you don't know what you're taking, there's the possibility of adverse health effects, and that's concerning," said Matt Fedoruk, USADA's chief science officer