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It acts as a selective inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme expressed in multiple tissues including adipose tissue and the liver that plays a role in cellular energy metabolism and fat storage

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Jan 2021;147:143-149

This is where methylcobalamin enters the conversation

GLP-1 agonists (semaglutide, tirzepatide) modulate insulin and glucagon secretion