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Concurrent application with highly acidic or strongly chelating topical agents-such as concentrated ascorbic-acid serums-may reduce the activity of one or both products because copper ions can catalyze oxidation reactions

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Schedule: Daily or every-other-day subcutaneous injections for 48 weeks

Clinical methods: the history, physical, and laboratory examinations Howard SC, McCormick J, Pui C-H, Buddington RK, Harvey RD (2016) Preventing and managing toxicities of high-dose methotrexate