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The most commonly reported relate to digestive discomfort, such as nausea or looser stools, and sometimes a more pronounced body odour

Warning signs include: Severe itching, rash, or hives at or beyond the injection site

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Compound 36 also exhibited good efficacy in oral glucose tolerance tests, demonstrating great DPP-4 inhibitory activity (IC 50 = 0.017 M) and moderate selectivity against DPP-4 in both ICR and KKAy mice

Therefore, maintaining optimal vitamin B-12 status could reduce the risk or delay onset by improving insulin sensitivity and glucose metabolism

This contrasts with later GLP-1 agents such as Victoza, Ozempic, and Mounjaro, which have demonstrated cardiovascular benefit