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Wegovy is usually prescribed to patients with a body mass index (BMI) of 30 or higher, or those with a secondary condition related to obesity, like knee pain or hypertension

318,319 Moreover, MCP-1 is a representative redundant chemokine that may be partially compensated for by other CC chemokines, potentially limiting its therapeutic consistency

This shift is driven by the parallel global epidemics of type 2 diabetes mellitus (T2DM) and obesity, which fuel the rise of metabolic dysfunction-associated steatotic liver disease (MASLD) (Danpanichkul et al., 2025