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CRISPR/Cas9-mediated knockout of autophagy regulators ATG5/ATG7 in RPMI-8226 MM cells significantly increased cell viability compared to wild-type controls upon RSL3-induced ferroptosis, confirming autophagys synergistic role in ferroptotic execution (Li and Lyu, 2024)

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Although higher concentrations may be more efficacious, a greater risk for paradoxical hyperpigmentation exists

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