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Medical care of adults with Down syndrome: A clinical guideline

In clinical studies, 400mg taken daily with diet and exercise supported meaningful reductions in BMI, waist, and hip measurements after just four weeks

Appl Surf Sci 358:146151

We dont want accumulating levels of homocysteine as it is a neurotoxin that has been linked to psychiatric disorders such as depression, schizophrenia, bipolar and Alzheimers disease (2)