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Central nervous system (CNS) development Although the action mechanisms of IGF-I in neurons have not been fully elucidated, it has been shown that IGF-I stimulates the autophosphorylation of IGF-IR[53] in a different manner to insulin[54]

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Traumatic brain injury is an increasingly recognized cause of AGHD and may occur without coexisting deficiencies in other anterior pituitary hormones (27)