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In preclinical and in vitro studies, GHK and GHK-Cu have been investigated in the context of copper-coordination chemistry, extracellular-matrix remodeling, collagen and metalloproteinase regulation, and antioxidant, anti-inflammatory, and gene-expression signaling

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Animal studies indicate that this peptide can alleviate symptoms of depression and anxiety, possibly through its interaction with serotonin pathways

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doi: 10.4162/nrp.2012.6.6.499 65 ShamardlHAMAIbrahimNAMerzebanDHElamirAMGolamRMElsayedAM

2f), confirming the importance of AP Gipr -expressing cells for mediating this action of GIPR agonism