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Previous studies also proved that: (1) mitochondrial dysfunction was closely associated with the variation in lipid accumulation in the liver (Reference Liao, Yan and Mai39,Reference Liao, Yan and Mai40)

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KPV acts directly on MC1R/MC4R receptors on macrophages and epithelial cells, reducing IL-6 and TNF- at the transcription level [7,8]

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