While it reversed the declining trend in 2021, it still lags significantly behind Keytruda, with sales nearly half of the latter's
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The shift in gut motility, combined with changes in bile acid absorption and fluid balance in the intestines, can lead to diarrhea, particularly during dose increases
In addition, a head-to-head trial of semaglutide and liraglutide was conducted in the STEP 8 trial, with a mean weight loss of 17.1% in the semaglutide group, which was significantly more effective than liraglutide (mean weight loss of 6.6%)

KEY TAKEAWAYS: Rising global burden of obesity, diabetes, hypertension, and cardiovascular diseases is accelerating demand for advanced cardiometabolic therapies Growing adoption of GLP-1 receptor agonists and SGLT2 inhibitors is transforming chronic disease management Increasing focus on integrated cardio-renal-metabolic care is improving patient outcomes and expanding therapeutic applications Advances in RNA-based therapeutics, gene-editing technologies, and precision medicine are creating new treatment opportunities Strong clinical pipelines targeting obesity, metabolic liver disease (MASH), lipid disorders, and heart failure are driving market expansion Strategic partnerships between pharmaceutical and biotechnology companies are accelerating drug development and commercialization North America leads the market due to advanced healthcare infrastructure, favorable reimbursement systems, and early adoption of innovative therapies, while Asia-Pacific is emerging as a high-growth region

Naltrexone-bupropion (Contrave) primarily causes nausea rather than diarrhea, affecting approximately 30% of users initially