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A 2025 post-hoc SURMOUNT-1 analysis ( Diabetes, Obesity and Metabolism ) confirmed Week 12 response is a strong predictor of long-term outcomes

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Uronis JM, Muhlbauer M, Herfarth HH, Rubinas TC, Jones GS, Jobin C

First, tirzepatide has been shown to increase the expression of brain-derived neurotrophic factor (BDNF) and phosphorylated cAMP response elementbinding protein (pCREB) [79], both of which are critical for neuronal growth and survival

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