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The findings that blockade of GLP-1 signalling abolished metformin-induced suppression of hepatic glucose output in rodents [13], and markedly attenuated the effect of metformin in reducing the glycaemic response to a mixed meal in people with type 2 diabetes [14], attest to a major role for GLP-1 in mediating the glucose-lowering effect of metformin

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But the extent of their success depends on what happens with EVOKE

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In contrast to the classically secreted proteins, the signal peptide is not cleaved off, but serves as a membrane anchor