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Moreover, somatostatin-positive interneurons (SST) seems to play a pivotal role in hippocampal oscillogenesis mainly supporting the theta rhythm (Park et al., 2020)
A spate of small molecules that inhibited OGA ( O-GlcNAcase ), an enzyme that modifies tau, have also failed in recent years
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As such, the model was used to simulate how long it would take pharmacologically and toxicologically relevant concentrations of doxorubicin to yield a 70% reduction in GSH concentration, indicative of impaired cellular antioxidant defence, protein binding and cell death 19