Liver injury in NAFLD is caused by two mechanisms in general: (1) by peripheral resistance to insulin, and (2) by intrahepatic oxidative stress, whether with an increase of reactive oxygen species and reactive nitrogen species (ROS and RNS) and/or as a result of the decrease in antioxidant tissue levels
The chronic accumulation of intracellular ROS seems to underlie the pathogenesis of these disorders
Taib N, Merhi M, Inchakalody V, et al
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