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Very low calorie diets below 800 calories daily should only be followed under medical supervision within a structured weight management programme, as unsupervised restriction can lead to nutritional deficiencies, muscle loss, gallstones, and electrolyte imbalances

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Chakravarthy added that the once-weekly injection petrelintide, an amylin-based drug, has a tolerability profile comparable to a placebo, which could provide an advantage