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The potential mechanism responsible for the increasing blood levels of 25(OH)VD could be that the improvement in the GSH status reduces oxidative stress and upregulates vitamin D-metabolizing genes, thereby increasing blood levels of 25(OH)VD (Figure 2)

216,217 Due to the reversible nature of epigenetics, identifying potential key epigenetic molecules affected by oxidative stress is expected to provide potential biomarkers and therapeutic targets for various human diseases

However, In the xenograft model, the inhibition of GPX4 restrain tumor regrowth after discontinuation of 5-FU treatment (Zhang X

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Key Points: Composed of three amino acids

This dual mechanism creates a robust antioxidant defense system that neutralizes reactive oxygen species before they can damage lipids, proteins, and DNA within the skin barrier