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Many agents also show favorable effects on body weight and some cardiovascular risk factors, which is why clinicians increasingly consider them for broader cardiometabolic indications

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Smoday IM, Petrovic I, Kalogjera L, Vranes H, Zizek H, Krezic I, et al

However, patients with severe obesity, poorly controlled type 2 diabetes, or those who still need aggressive weight reduction often do better from staying on injectable therapy because it tends to be more powerful at higher doses