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On the other hand, the gene expression of mitochondrial biogenesis markers ( PGC1 , AMPK , SIRT1 , NRF2 , and MFN2 ) and mitochondrial activity marker ( COXIV ) in liver-specific GHRKO (LiGHRKO) and wild-type mice are significantly different between the males and females, suggesting that sexual dimorphism may also play an essential role in regulating the mitochondrial biogenesis (Zawada et al., 2015)

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IGF-1 LR3 is engineered with an N-terminal extension and Arg3 substitution that reduces IGFBP-3 binding, extending its effective activity substantially longer in preclinical models

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All four medications can cause gastrointestinal side effects, but when they occur and how severe they are can vary from one medication to another

V., Awasthi, Y