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Collagen is a structural protein responsible for maintaining skin elasticity (61)

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Diabetes 45 , 531535 (1996)

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The STEP 1 trial showed semaglutide 2.4 mg led to 14.9% weight loss over 68 weeks, while SURMOUNT-1 showed tirzepatide achieved up to 20.9% weight reductionapproaching bariatric surgery outcomes.[6] The SELECT trial (17,604 patients) found semaglutide reduced cardiovascular death, non-fatal heart attack, and non-fatal stroke by 20% and all-cause mortality by 19%, suggesting direct cardioprotective effects beyond weight loss.[4] In STEP-HFpEF, semaglutide produced 13.3% weight loss in heart failure patients and improved symptoms and physical function

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There has been significant progress toward the identification of the transcriptional, proteomic, and metabolic changes accompanying the induction and development of CI in apples and pears by omics approaches

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